Innovative Drug Delivery Solution: The Integration of Microorganism Micro-Engine and Microneedle Technology
1. Overview of Microneedle Technology and Its Limitations 1.1 Overview of Microneedles Microneedles are a minimally invasive transdermal drug delivery technology designed to penetrate the stratum corneum, enabling effective drug administration. Unlike traditional hypodermic needles, microneedles are short and fine, causing minimal pain and reducing the risk of infection by avoiding direct contact with nerves and blood vessels. This technology is widely applied in drug delivery, vaccine administration, gene therapy, and cosmetic dermatology. 1.2 Mechanism of Microneedles Microneedles penetrate the outermost layer of the skin, the stratum corneum , and deliver drugs into the epidermis or dermis . Compared to conventional transdermal patches, microneedles enable deeper and more effective drug penetration. Microneedles can be classified into the following types: Solid Microneedles Create micro-channels in the skin for subsequent drug absorption. Improve...